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Modification of the U.S.P. dissolution method for the analysis of norethindrone and ethinyl estradiol tablets

✍ Scribed by Angelica Dorantes; Salomon Stavchansky

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
344 KB
Volume
83
Category
Article
ISSN
0022-3549

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✦ Synopsis

A modification of the U.S.P. dissolution method for the quantitation of norethindrone and ethinyl estradiol tablets is proposed. This modification consists of the use of distilled water as the dissolution medium instead of 0.1 N hydrochloric acid (HCI) and/or neutralization of 0.1 N HCI with sodium carbonate prior to analysis. Statistical analysis of the results indicate that there are no significant differences between the dissolution in 0.1 N HCI and the dissolution in distilled water (p < 0.05) for norethindrone and ethinyl estradiol.

and distilled water (Table 1). The relative SDs are not >3 % ,

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Development and validation of a high-sensitivity liquid chromatography/tandem mass spectrometry (LC/MS/MS) method with chemical derivatization for the determination of ethinyl estradiol in human plasma
✍ Wilson Z. Shou; Xiangyu Jiang; Weng Naidong πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 192 KB πŸ‘ 2 views

## Abstract An ultra‐sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the analysis of oral contraceptive ethinyl estradiol (EE) was developed and validated over the curve range of 2.5–500 pg/mL using 1 mL of human plasma sample. Ethinyl estradiol and the internal stand