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Modification of the polar head group of platelet-activating factor: Influence on the biological activity

✍ Scribed by G. Ostermann; H.-P. Kertscher; A. Lang; U. Till

Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
392 KB
Volume
43
Category
Article
ISSN
0009-3084

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✦ Synopsis

Racemic analogues of platelet-activating factor and its lyso derivatives have been prepared in which one methyl of the trimethylammonium group has been replaced by ethyl, propyl, allyl, or carboxymethylene. The influence of chemical modification on the biological activity was assessed by measuring platelet aggregation and desensitization. The results point to a crucial role of a positively charged polar head group for the expression of biological activity of platelet-activating factor. There are also some indications of a more non-specific interaction of the polar head group of platelet-activating factor with its platelet binding sites.

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