Modification of the glyoxalase system in human HL60 promyelocytic leukemia cells during differentiation to neutrophils in vitro
β Scribed by Hooper, Nigel I.; Tisdale, Michel J.; Thornalley, Paul J.
- Book ID
- 122446121
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 646 KB
- Volume
- 966
- Category
- Article
- ISSN
- 0304-4165
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The role of magnesium ions in the differentiation of human promyelocytic leukemia HL-60 cells was investigated. When HL-60 extracellular magnesium was deficient (less than 0.01 mM), the total intracellular magnesium content and [3H] leucine incorporation rates decreased to 61 and 28%, respectively,
## Abstract We have tested the effect of several bile acids on the proliferation and differentiation of the HL60 human promyelocytic leukemia cell line __in vitro__. Deoxycholate, chenodeoxycholate and lithocholic acid caused doseβdependent inhibition of cell proliferation and induction of differen