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Modification of peptide interaction with MHC creates TCR partial agonists

✍ Scribed by Kelli R. Ryan; Lisa K. McNeil; Chinh Dao; Peter E. Jensen; Brian D. Evavold


Book ID
113526756
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
289 KB
Volume
227
Category
Article
ISSN
0008-8749

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The activation of T lymphocytes is initiated by the binding of MHC-peptide complexes on antigen-presenting cells to MHC-restricted, peptide specific TCRs. Significant progress has recently been made in understanding the structure of the TCR and in the direct quantitative examination of the primary b