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Modification of morphine withdrawal in rats by alterations of the endogenous opioid system: Effects of actinonin and GEMSA

✍ Scribed by Eleonora D. Dzoljic; Mihailo R. Dzoljic

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
421 KB
Volume
18
Category
Article
ISSN
0272-4391

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✦ Synopsis

The results show that actinonin (50-200 pg, i.c.v.), an inhibitor of the three enzymes involved in the biodegradation of enkephalins, attenuates, while guanidinoethylmercaptosuccinic acid (GEMSA 3-1 2 Fg, i.c.v.), an inhibitor of enkephalin-synthesising carboxypeptidase, aggravates some naloxone-precipitated withdrawal signs in chronic morphine-dependent rats. The results suggest that alterations in the functional activity of the endogenous opioid system by drugs that affect enkephalin metabolism might have a significant effect on the severity of opiate withdrawal.

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