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Modification of microsomal enzyme activity and parathion toxicity in rats

โœ Scribed by D. C. Villeneuve; W. E. J. Phillips; John Syrotiuk

Book ID
112576179
Publisher
Springer
Year
1970
Tongue
English
Weight
331 KB
Volume
5
Category
Article
ISSN
0007-4861

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A kinetic analysis of cytochrome P450mediated desulfuration (activation) or dearylation (detoxication) showed that rat hepatic microsomes have a greater capacity to detoxify and a lower capacity to activate chlorpyrifos compared to parathion. Kinetic curves for the desulfuration of both parathion an