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Modification of Galactose Oxidase to Introduce Glucose 6-Oxidase Activity

✍ Scribed by Lianhong Sun; Thomas Bulter; Miguel Alcalde; Ioanna P. Petrounia; Frances H. Arnold


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
81 KB
Volume
3
Category
Article
ISSN
1439-4227

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## Abstract Hyperglycemia‐induced generation of reactive oxygen species (ROS) can lead to cardiomyocyte apoptosis and cardiac dysfunction. However, the mechanism by which high glucose causes cardiomyocyte apoptosis is not clear. In this study, we investigated the signaling pathways involved in NADP