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Modification of DNA with Octadiynyl Side Chains: Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne−Azide “Click” Reaction

✍ Scribed by Seela, Frank; Sirivolu, Venkata Ramana; Chittepu, Padmaja

Book ID: 111972359
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 541 KB
Volume: 19
Category: Article
ISSN: 1043-1802
DOI: 10.1021/bc700300f

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## Abstract 5‐Tripropargylamine‐2′‐deoxyuridine (**1 a**) containing two terminal triple bonds was synthesized by a Pd‐assisted Sonogashira cross‐coupling reaction and was subsequently converted into the corresponding phosphoramidite building block (**9**) and employed in solid‐phase oligonucleotid