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Modification of DNA Ends Can Decrease End Joining Relative to Homologous Recombination in Mammalian Cells

✍ Scribed by Xiu-Bao Chang and John H. Wilson


Book ID
123634743
Publisher
National Academy of Sciences
Year
1987
Tongue
English
Weight
844 KB
Volume
84
Category
Article
ISSN
0027-8424

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The end-joining pathway of DNA double-strand break (DSB) repair is necessary for proper V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair pathway can either use short stretches of (micro)homology near the DNA ends or use no homology at all (direct end-joining). We d