Modern Ointment Base Technology I.:Properties of Hydrocarbon Gels*
✍ Scribed by Mutimer, Margaret N. ;Riffkin, Charles ;Hill, John A. ;Cyr, Gilman N.
- Publisher
- Elsevier
- Year
- 1956
- Weight
- 482 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0095-9553
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✦ Synopsis
The disadvantages of petrolatum as an ointment base, i.e., greasiness, stickiness, and viscosity-temperature variations, can largely be overcome by the use of mineral oil gelled with certain waxes or resins, particular1 olyethylene resin. The most desirable hydrocarbon gel appears to be one m a d g y the very rapid chilling of a hot mixture consisting of 5 per cent polyethylene resin in U. S. P. liquid petrolatum. The critical factors in producing a good gel are: (a) the molecular weight of the polyethylene, (b) the percentage of polyethylene, (c) the viscosity of the mineral oil, and * Received May 6. 1955, from The Squibb Institute for M a t e d to <he Scientific Sdtion, 'A. PH. A.. Miami Medical Research New Bruaswick N. J Beach meeting, May 1955.
Petrolatum is a typical hydrocarbon gel. A study of it and other hydrocarbon gels will provide information indicative of the type of gel structure necessary for ideal ointment bases.