Hypothalamic leptin gene therapy prevent
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Urszula T Iwaniec; StΓ©phane Boghossian; Cynthia H Trevisiol; Thomas J Wronski; R
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Article
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2011
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American Society for Bone and Mineral Research
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English
β 964 KB
## Abstract Hypothalamic leptin gene therapy normalizes the mosaic skeletal phenotype of leptinβdeficient __ob/ob__ mice. However, it is not clear whether increased hypothalamic leptin alters bone metabolism in animals already producing the hormone. The objective of this study was to evaluate the l