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Models of natural mutations including site heterogeneity

โœ Scribed by Jeffrey M. Koshi; Richard A. Goldstein

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
92 KB
Volume
32
Category
Article
ISSN
0887-3585

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โœฆ Synopsis

New computational models of natural site mutations are developed that account for the different selective pressures acting on different locations in the protein. The number of adjustable parameters is greatly reduced by basing the models on the underlying physical-chemical properties of the amino acids. This allows us to use our method on small data sets built of specific protein types. We demonstrate that with this approach we can represent the evolutionary patterns in HIV envelope proteins far better than with more traditional methods. Proteins 32:289-295, 1998.

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