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MODELS OF AMYLOID SEEDING IN ALZHEIMER'S DISEASE AND SCRAPIE:Mechanistic Truths and Physiological Consequences of the Time-Dependent Solubility of Amyloid Proteins

✍ Scribed by Harper, James D.; Lansbury, Peter T.

Book ID: 118039182
Publisher: Annual Reviews
Year: 1997
Tongue: English
Weight: 202 KB
Volume: 66
Category: Article
ISSN: 0066-4154
DOI: 10.1146/annurev.biochem.66.1.385

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## Abstract Proteolytic processing of the amyloid precursor protein by β ‐and γ‐secretases results in the production of Alzheimer's disease (AD) Aβ amyloid peptides. Modulation of secretase activity is being investigated as a potential therapeutic approach. Recent studies with human brain have reve