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Models for antigen receptor gene rearrangement: CDR3 length

✍ Scribed by Saada, Ravit; Weinberger, Moran; Shahaf, Gitit; Mehr, Ramit

Book ID
110041409
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
363 KB
Volume
85
Category
Article
ISSN
0818-9641

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Despite the various processing steps involved in V(D)J recombination, which could potentially introduce many biases in the length distribution of complementarity determining region 3 (CDR3) segments, the observed CDR3 length distributions for complete repertoires are very close to a normal‐like dist

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Two specialized forms of site-directed double-strand (ds) DNA breakage and rejoining are part of the physiologic program of lymphocytes. One is recombination of the V, D and J gene sequences, termed V(D).I recombination, occurring during early B-and T-cell development, and the other is class switch