MODELLING TRANSANNULAR CYCLIZATION OF 1(10)E,4E-GERMACRANOLIDE COSTUNOLIDE INTO EUDESMANE DERIVATIVES
✍ Scribed by B. B. Khasenov; K. M. Turdybekov
- Book ID
- 110328788
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 44 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0009-3130
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The acid-and enzyme-catalysed cyclisations of a number of (Z,E)-1(10),4-cyclodecadiene derivatives were investigated. In contrast to the regular transannular C-C bond formation as observed for (E,E)-I ( I 0),4-cyclodecadiene systems, these melampolide-like systems cyclised via a number of different
## Abstract Cyclization of ethyl (__E__)/(__Z__)‐[2‐(1‐cyclohexen‐1‐yl)cyclohexylidene]cyanoacetate (2) in cold concentrated sulfuric acid affords 10‐amino‐1,2,3,4,5,6,7,8‐octahydrophenanthrene‐9‐carboxylic acid (4) and 3,5,6,7,8,8a‐hexahydro‐3‐oxospiro‐[1__H__‐2‐benzopyran‐1,1′‐cyclohexane]‐4‐carb