Diffusely infiltrating low-grade astrocytomas (WHO grade II) have an intrinsic tendency for progression to anaplastic astrocytoma (WHO grade III) and glioblastoma (WHO grade IV). This change is due to the sequential acquisition of genetic alterations, several of which have recently been identified.
Modelling the evolution of genetic instability during tumour progression
β Scribed by S. Datta, Ruchira; Gutteridge, Alice; Swanton, Charles; Maley, Carlo C.; Graham, Trevor A.
- Book ID
- 119828525
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2012
- Tongue
- English
- Weight
- 674 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1752-4563
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