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Modelling ordinal responses from co-twin control studies

✍ Scribed by Frank B. Hu; Jack Goldberg; Donald Hedeker; William G. Henderson

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
121 KB
Volume
17
Category
Article
ISSN
0277-6715

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✦ Synopsis

The co-twin control design has been widely used in studying the effects of environmental factors on the development of diseases. For binary outcomes that arise from co-twin control studies, the conditional likelihood method is commonly used. This approach, however, does not readily extend to ordinal response data because the standard conditional likelihood does not exist for cumulative logit or proportional odds models. In this paper, we investigate the applicability of the random-effects and GEE approaches in analysing ordinal response data from co-twin control studies. Using both approaches, we re-analyse data from a co-twin control study of the impact of military services during the Vietnam era on post-traumatic stress disorders (PTSD). The ordinal models have considerably increased power in detecting the effects of exposure when compared to the analyses using a dichotomized response. We discuss the interpretation of the estimates from GEE and random-effects models in the context of the twin data.

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