Modelling of the enteric nervous network: 3. Adrenergic neuron

✍ Scribed by R.N. Miftakhov; D.L. Wingate

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 978 KB
• Volume: 16
• Category: Article
• ISSN: 1350-4533
• DOI: 10.1016/1350-4533(94)90068-x

✦ Synopsis

A mathematical moo% is developed to investigate the coupled electrochemical processes of newe-pulsr transmission via adrenergic synapse. Based on pharmacological and morphophysiological da&a, the model describes the dynamics of the propagation oJ the electric signal along the unmyelinated geometrically non-uniform axon of the neuron and the rhemical mechanisms oJ the transJin-rnation of the electrical signal in the synaptic zone into the post-synaptic output. The combined nonlinear system o/partial and ordinary diff erential equations has been obtained and solved numerically. The results of computer simulation of the Junction of the idealized adrenerpk neuron quantitatively ' and qualitatively describe the dynamics oJ Ca '+ ion influx into the terminal, noradrenaline rekase from the free 'releasable' store, its dzJJusion into the synaptic cleft, binding with the adrenoceptors on the pre-and post-synaptic structures with the generation oJ the inhibitory post-synaptic potential, and utilization oJ noradrenaline by neuronal and non-neuronal capture mechanisms.