Modelling of L-lysine fed-batch culture based on combined neural network estimators

✍ Scribed by Y. -P. I; Y. -C. Liu; W. -T. Wu

• Book ID: 104744310
• Publisher: Springer
• Year: 1995
• Tongue: English
• Weight: 552 KB
• Volume: 13
• Category: Article
• ISSN: 1615-7605
• DOI: 10.1007/bf00369565

✦ Synopsis

Modelling of a bioprocess was developed by combining three neural network estimators (NNEs). The bioprocess was for fed-batch culture of L-lysine production. The NNEs were NNE1, NNE2, and NNE3. NNE1 was applied to estimate the consumed sugar concentration, L-lysine concentration, and cell optical density. NNE2 was utilized to determine the off-gas concentration of O2 and CO2 while NNE3 was employed to predict the agitation speed. These NNEs possessed their own distinct functions and could be used independently. Combination of the NNEs based on neural network gave an easy and significant way for modelling a bioprocess.