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Modelling of anti-HSV activity of lactoferricin analogues using amino acid descriptors

✍ Scribed by Håvard Jenssen; Tore J. Gutteberg; Tore Lejon

Book ID
105360417
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
104 KB
Volume
11
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

Herpes simplex virus (HSV) causes a number of diseases and new therapies are being pursued vigorously. Earlier studies have shown that modified peptides based on lactoferricins reduce HSV‐1 and HSV‐2 infection, and structure–activity studies indicate that the anti‐viral activity correlates with the binding affinity for heparan sulphate and chondroitin sulphate. In this study it is shown that theoretically derived amino acid descriptors can be used to model the anti‐viral activity of peptides, as well as other peptide properties, even more accurately. Copyright © 2004 European Peptide Society and John Wiley & Sons, Ltd.

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Antibiotic activity of pentadecapeptides
Antibiotic activity of pentadecapeptides modelled from amino acid descriptors
✍ Tore Lejon; Morten B. Strøm; John S. Svendsen 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB

## Abstract Pentadecapeptides based on modified murine lactoferricin (LFM) sequences show varying degrees of antibacterial activity against __Escherichia coli__ and __Staphylococcus aureus__. By means of projections to latent structures (PLS), a good correlation is obtained if the biological activi