✍ Scribed by François Képès; Alessandra Carbone
No coin nor oath required. For personal study only.
Two meetings were recently held in Paris and Evry under the auspices of the publically-funded research/biotech agency genopole 1 and of the Institut des Hautes Etudes Scientifiques. The first was a symposium, held July 8-11, 2002, which was devoted to ''Macromolecular Networks'', while the second was a workshop, which immediately followed the main meeting, July12-13, 2002, which was devoted to ''Regulatory protein interplay and traffic on DNA''. The Symposium focused on recent conceptual insights for identifying the dynamics of macromolecular interactions, the morphodynamics of biological structures and the nature of epigenetic processes. The Workshop concentrated on the control of macromolecular traffic on DNA and the interplay between regulating proteins acting on the same target gene. The sources of information for both were the rapidly growing amount of genomic, transcriptomic and proteomic data.
Addressing these issues requires interdisciplinary approaches, a fact reflected by the variety of scientific backgrounds of both speakers and audience.
In this report, we shall attempt to capture some of the spirit of these meetings, rather than trying to give a detailed summary of the findings; we apologize for any involuntary mis-or under-representations. Both meetings were coorganized with Paul Bourgine (CREA, CNRS/Ecole Polytechnique) and Misha Gromov (IHES).
Macromolecular networks come in three major flavours: metabolic networks, where interactions mostly involve enzymatic proteins and small molecules or metabolites proteinprotein interaction networks and genetic networks, where
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