Modelling ‘evo-devo’ with RNA

✍ Scribed by Walter Fontana

• Book ID: 101705159
• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 476 KB
• Volume: 24
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.10190

✦ Synopsis

Abstract

The folding of RNA sequences into secondary structures is a simple yet biophysically grounded model of a genotype–phenotype map. Its computational and mathematical analysis has uncovered a surprisingly rich statistical structure characterized by shape space covering, neutral networks and plastogenetic congruence. I review these concepts and discuss their evolutionary implications. BioEssays 24:1164–1177, 2002. © 2002 Wiley‐Periodicals, Inc.