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Modelling atypical CYP3A4 kinetics: principles and pragmatism

✍ Scribed by J. Brian Houston; Aleksandra Galetin


Book ID
116177155
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
650 KB
Volume
433
Category
Article
ISSN
0003-9861

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## Abstract This work presents a method to utilize the ever‐expanding corporate collections of CYP450 inhibition data to forecast the future risk of compounds not yet synthesized. The global/local fusion method differs from existing QSAR methods, in that each prediction is derived from a custom‐bui