Modeling the T-helper cell response in acute and chronic hepatitis B virus infection using T-cell receptor transgenic mice
✍ Scribed by M Chen; M Sällberg; S.N Thung; J Hughes; J Jones; David R Milich
- Book ID
- 114144350
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 534 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0166-3542
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Chronic hepatitis B virus (HBV) infection is characterized by a weak immune response to HBV. Regulatory T cells (T(reg)) can suppress the function of effector T cells and may thus be key players in this impaired immune response. Changes in the functionality or number of T(reg) could explain the decr
## Hepatitis B virus (HBV)-specific T cells play a key role in clearance of the virus and in the pathogenesis of liver disease. Peripheral blood (n ؍ 25) and liver biopsies (n ؍ 19) were collected from individuals with chronic untreated HBV infection. Whole blood, cultured peripheral blood mon