Modeling the Short- and Long-Duration Responses to Exogenous Levodopa and to Endogenous Levodopa Production in Parkinson's Disease
β Scribed by Phylinda L. S. Chan; John G. Nutt; Nicholas H. G. Holford
- Book ID
- 111594073
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 292 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1573-8744
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We examined the response to 2-hour levodopa infusions in 18 Parkinson's disease subjects before starting long-term levodopa treatment and after 6 and 12 months of treatment using tapping speed as an index of bradykinesia. The long-duration response (LDR), measured as the increase in baseline (overni
In 92 parkinsonian patients (42 men, 50 women) aged from 37-79 years (mean 62.8) the impact of cerebral atrophy as assessed by computed tomography on the course of the clinical symptomatology under levodopa during a period of 1 to 5 years was investigated. It could be shown that patients suffering f