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Modeling the role of two susceptibility loci by the MASC method

✍ Scribed by Dr. Marie-Hélène Dizier; Marie-Claude Babron; Françoise Clerget-Darpoux

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
297 KB
Volume
12
Category
Article
ISSN
0741-0395

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✦ Synopsis

Abstract

Two susceptibility genes, in linkage disequilibrium with alleles of the markers D1G31 and D5G23, have been identified for the disease in the simulated data set of Problem 1. Here we apply the MASC (marker association segregation chi‐square) method to model the joint effect of these two genes, by testing two‐locus models. The model we obtain, that is the most parsimonious and that best fits the data, corresponds to a direct involvement of the alleles D1G31‐8 and D5G23‐7, with a nonmultiplicative effect of the two alleles. This was indeed assumed in the true model used for simulating the data. ©1995 Wiley‐Liss, Inc.

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