Modeling the Phase Behavior in Mixtures of Pharmaceuticals with Liquid or Supercritical Solvents
β Scribed by Tsivintzelis, Ioannis; Economou, Ioannis G.; Kontogeorgis, Georgios M.
- Book ID
- 119996578
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 795 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0022-3654
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## Abstract A methodology is suggested for modeling the phase equilibria of complex chemical mixtures with an equation of state (EoS) for the case where only limited experimental data exist. The complex hydrogen bonding behavior is explicitly accounted for and the corresponding parameters are adopt
The knowledge of the solubility of pharmaceuticals in pure solvents and solvent mixtures is crucial for designing the crystallization process of drug substances. The first step in finding optimal crystallization conditions is usually a solvent screening. Since experiments are very time consuming, a