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Modeling the Insulin–Glucose Feedback System: The Significance of Pulsatile Insulin Secretion

✍ Scribed by IVA MARIJA TOLIĆ; ERIK MOSEKILDE; JEPPE STURIS

Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
242 KB
Volume
207
Category
Article
ISSN
0022-5193

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✦ Synopsis

A mathematical model of the insulin}glucose feedback regulation in man is used to examine the e!ects of an oscillatory supply of insulin compared to a constant supply at the same average rate. We show that interactions between the oscillatory insulin supply and the receptor dynamics can be of minute signi"cance only. It is possible, however, to interpret seemingly con#icting results of clinical studies in terms of their di!erent experimental conditions with respect to the hepatic glucose release. If this release is operating near an upper limit, an oscillatory insulin supply will be more e$cient in lowering the blood glucose level than a constant supply. If the insulin level is high enough for the hepatic release of glucose to nearly vanish, the opposite e!ect is observed. For insulin concentrations close to the point of in#ection of the insulin}glucose dose}response curve an oscillatory and a constant insulin infusion produce similar e!ects.

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## Abstract ## Background Age is associated with both impaired glucose and insulin metabolism. To what extent the age‐related changes in insulin resistance (IR) and β‐cell function contribute to the increase in prevalence of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) is le