Modeling mechanosensing and its effect o
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Pedro Moreo; JosΓ© Manuel GarcΓa-Aznar; Manuel DoblarΓ©
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Article
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2008
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Elsevier Science
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English
β 664 KB
The behavior of normal adherent cells is influenced by the stiffness of the substrate they are anchored to. Cells are able to detect substrate mechanical properties by actively generating contractile forces and use this information to migrate and proliferate. In particular, the speed and direction o