Modeling of inhibitor–metalloenzyme inte
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David R. Garmer; Nohad Gresh; Bernard-Pierre Roques
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Article
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1998
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John Wiley and Sons
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English
⚖ 365 KB
👁 1 views
We investigated the binding properties of the metalloprotease inhibitors hydroxamate, methanethiolate, and methylphosphoramidate to a model coordination site occurring in several Zn2؉ metalloproteases, including thermolysin. This was carried out using both the SIBFA (sum of interactions between frag