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Modeling of the mechanism of hydrolysis of succinylcholine in the active site of native and modified (Asp70Gly) human butyrylcholinesterase

✍ Scribed by S. V. Lushchekina; B. L. Grigorenko; D. I. Morozov; I. V. Polyakov; A. V. Nemukhin; S. D. Varfolomeev


Book ID
106521492
Publisher
Springer
Year
2010
Tongue
English
Weight
437 KB
Volume
59
Category
Article
ISSN
1573-9171

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In humans, the plasma enzyme butyrylcholinesterase, BChE (EC 3.1.1.8), mediates the in vivo plasma hydrolysis of cocaine to the pharmacologically inactive metabolite ecgonine methyl ester, EME. This enzyme has been purified from human plasma to investigate the potential as a treatment for cocaine in