Modeling of Human Cytochrome P450-Mediated Drug Metabolism Using Unsupervised Machine Learning Approach
โ Scribed by Korolev, Dmitry; Balakin, Konstantin V.; Nikolsky, Yuri; Kirillov, Eugene; Ivanenkov, Yan A.; Savchuk, Nikolay P.; Ivashchenko, Andrey A.; Nikolskaya, Tatiana
- Book ID
- 115519704
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 682 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
We previously clarified that major human drug metabolizing enzymes were expressed in a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line established recently, in which the liver could be replaced by more than 80% with human hepatocytes. In the p
## Abstract In the drug discovery process, it is important to know the properties of both drug candidates and their metabolites. Fast and precise prediction of metabolites is essential. However, it has been difficult to predict metabolites because of the complexity of the mechanism of cytochrome P4