✦ LIBER ✦

Modeling of Diffusion with Partitioning in Stratum Corneum Using a Finite Element Model

✍ Scribed by Ana M. Barbero; H. F. Frasch

Publisher: Springer
Year: 2005
Tongue: English
Weight: 440 KB
Volume: 33
Category: Article
ISSN: 0090-6964
DOI: 10.1007/s10439-005-5591-4

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Transcellular route of diffusion through

Transcellular route of diffusion through stratum corneum: Results from finite element models

✍ Ana M. Barbero; H. Frederick Frasch 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB

Insight into the stratum corneum (SC) permeation pathway for hydrophilic compounds is gained by comparing experimental measurements of permeability and lag time (tlag) with the predictions of a finite element (FE) model. A database of permeability and lag time measurements (n=27) of hydrophilic comp

Finite Element Modeling of Coupled Diffu

Finite Element Modeling of Coupled Diffusion with Partitioning in Transdermal Drug Delivery

✍ Jee E. Rim; Peter M. Pinsky; William W. Osdol 📂 Article 📅 2005 🏛 Springer 🌐 English ⚖ 929 KB

Steady-state flux and lag time in the st

Steady-state flux and lag time in the stratum corneum lipid pathway: Results from finite element models

✍ H. Frederick Frasch; Ana M. Barbero 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 197 KB

Finite element model (FEM) solutions of the diffusion through two-dimensional representations of the stratum corneum (SC) lipid pathway are presented. Both simplified, regular "brick and mortar" models and a more complex, irregular model are analyzed. It is assumed that diffusion occurs only within

Diffusion modeling of percutaneous absor

Diffusion modeling of percutaneous absorption kinetics: 3. Variable diffusion and partition coefficients, consequences for stratum corneum depth profiles and desorption kinetics

✍ Yuri G. Anissimov; Michael S. Roberts 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB

Stratum corneum (SC) desorption experiments have yielded higher calculated steady-state fluxes than those obtained by epidermal penetration studies. A possible explanation of this result is a variable diffusion or partition coefficient across the SC. We therefore developed the diffusion model for pe

Erratum: Steady-state flux and lag time

Erratum: Steady-state flux and lag time in the stratum corneum lipid pathway: Results from finite element models

✍ H. Frederick Frasch; Ana M. Barbero 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 38 KB

First-principles, structure-based transd

First-principles, structure-based transdermal transport model to evaluate lipid partition and diffusion coefficients of hydrophobic permeants solely from stratum corneum permeation experiments

✍ Joseph Kushner IV; William Deen; Daniel Blankschtein; Robert Langer 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 329 KB

To account for the effect of branched, parallel transport pathways in the intercellular domain of the stratum corneum (SC) on the passive transdermal transport of hydrophobic permeants, we have developed, from first-principles, a new theoretical model-the Two-Tortuosity Model. This new model require