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Modeling of brain metabolism and pyruvate compartmentation using 13C NMR in vivo: caution required

✍ Scribed by Jeffrey, F Mark; Marin-Valencia, Isaac; Good, Levi B; Shestov, Alexander A; Henry, Pierre-Gilles; Pascual, Juan M; Malloy, Craig R

Book ID
120592806
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
424 KB
Volume
33
Category
Article
ISSN
0271-678X

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In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients nece