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Modeling myeloid leukemia tumor suppressor gene inactivation in the mouse

✍ Scribed by Kevin M Shannon; Michelle M Le Beau; David A Largaespada; Nigel Killeen

Book ID
112265030
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
320 KB
Volume
11
Category
Article
ISSN
1044-579X

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## Abstract Hypermethylator phenotype, a propensity of tumors to incur nonrandom concurrent methylation, has been described in several tumors, including acute myeloid leukemia (AML). More recent studies identified methylation of other tumor suppressor genes, DAP‐kinase and SOCS1, singly in AML. We