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Modeling Hybridoma Cell Metabolism Using a Generic Genome-Scale Metabolic Model of Mus musculus

✍ Scribed by Kashif Sheikh; Jochen Förster; Lars K. Nielsen

Book ID
109387129
Publisher
American Institute of Chemical Engineers
Year
2008
Tongue
English
Weight
165 KB
Volume
21
Category
Article
ISSN
8756-7938

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## Abstract Genome‐scale modeling of mouse hybridoma cells producing monoclonal antibodies (mAb) was performed to elucidate their physiological and metabolic states during fed‐batch cell culture. Initially, feed media nutrients were monitored to identify key components among carbon sources and amin