Modeling hippocampal theta oscillation: Applications in neuropharmacology and robot navigation

✍ Scribed by Tamás Kiss; Gergő Orbán; Péter Érdi

• Book ID: 102279997
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 247 KB
• Volume: 21
• Category: Article
• ISSN: 0884-8173
• DOI: 10.1002/int.20168

✦ Synopsis

This article introduces a biologically realistic mathematical, computational model of theta ~Ϸ5 Hz! rhythm generation in the hippocampal CA1 region and some of its possible further applications in drug discovery and in robotic/computational models of navigation. The model shown here uses the conductance-based description of nerve cells: Populations of basket cells, alveus/lacunosum-moleculare interneurons, and pyramidal cells are used to model the hippocampal CA1 and a fast-spiking GABAergic interneuron population for modeling the septal influence. Results of the model show that the septo-hippocampal feedback loop is capable of robust theta rhythm generation due to proper timing of pyramidal cells and synchronization within the basket cell network via recurrent connections.