Modeling high-biomass-density cell recycle fermentors

✍ Scribed by Harold G. Monbouquette

• Book ID: 102771241
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 591 KB
• Volume: 39
• Category: Article
• ISSN: 0006-3592
• DOI: 10.1002/bit.260390504

✦ Synopsis

Since intrinsic models, which take into account cell volume fraction, follow from proper application of the law of conservation of mass to a multiphase system, the intrinsic modeling approach should be used whenever biomass occupies a significant volume fraction of the culture. A recent report" offers the first comparison of intrinsic and nonintrinsic model predictions to actual experimental data gathered from a high-density yeast recycle fermentor. Here, the analy- sis of Jarzebski et al." has been carried further to show that the improper nonintrinsic model predicts a steady-state culture glucose concentration that differs from that given by the fundamentally correct intrinsic model by over 60% at the optimal bleed stream flow rate. In addition, a revised formulation for an intrinsic ethanol mass balance is presented.