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Modeling Heterogeneity of Particles and Random Effects in Drug Dissolution

✍ Scribed by Petr Lánský; Michael Weiss

Book ID
110295580
Publisher
Springer US
Year
2001
Tongue
English
Weight
153 KB
Volume
18
Category
Article
ISSN
0724-8741

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The purpose of the present study was to construct the theoretical dissolution model of poly-disperse drug particles in biorelevant media containing bile salt/ lecithin aggregates (micelles or vesicles). The effective diffusion coefficient in the biorelevant medium and the particle size distribution