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Modeling Fetal Death and Malformation in Developmental Toxicity Studies

✍ Scribed by Paul Catalano; Louise Ryan; Daniel Scharfstein

Book ID
109156998
Publisher
Springer
Year
1994
Tongue
English
Weight
620 KB
Volume
14
Category
Article
ISSN
1573-9147

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Caprolactam was evaluated for developmental toxicity potential in both rats and rabbits by the oral route. In rats dosed on days 6-15 of gestation with 100,500 or 1000 mg/kg/day of caprolactam, the maternal survival rate was significantly lower in the high-dose group and implantation efficiencies we