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Modeling Cardiac Uptake and Negative Inotropic Response of Verapamil in Rat Heart: Effect of Amiodarone

✍ Scribed by Pakawadee Sermsappasuk; Osama Abdelrahman; Michael Weiss

Book ID
106492930
Publisher
Springer US
Year
2006
Tongue
English
Weight
393 KB
Volume
24
Category
Article
ISSN
0724-8741

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Cardiac pharmacokinetics and inotropic r
Cardiac pharmacokinetics and inotropic response of verapamil in rats with endotoxemia
✍ Pakawadee Sermsappasuk; Osama Abdelrahman; Michael Weiss πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 126 KB

The present study evaluated the effect of endotoxin-induced systemic inflammation on cardiac uptake and negative inotropic response to verapamil in isolated rat hearts. Rats received an i.p. dose of 4 mg/kg Escherichia coli lipopolysaccharide (LPS) or saline. After 5.5 h the outflow concentration-ti