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Modeling and Analysis of Calcium Signaling Events Leading to Long-Term Depression in Cerebellar Purkinje Cells

โœ Scribed by Hernjak, Nicholas; Slepchenko, Boris M.; Fernald, Kathleen; Fink, Charles C.; Fortin, Dale; Moraru, Ion I.; Watras, James; Loew, Leslie M.


Book ID
119919630
Publisher
Biophysical Society
Year
2005
Tongue
English
Weight
572 KB
Volume
89
Category
Article
ISSN
0006-3495

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Using an in vitro slice preparation, we studied the effects, on parallel fiber (PF)-mediated EPSPs, of coactivation of metabotropic-glutamate receptors and of voltage-gated calcium (Ca) channels of Purkinje cells (PCs) by bath application of 50 microM trans-1-amino-cyclopentyl-1,3-dicarboxylate (tra