Model systems for flavoenzyme activity. The effects of specific hydrogen bonds on the 13C and 1H NMR of flavins

✍ Scribed by Angelika Niemz; Vincent M. Rotello

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 394 KB
• Volume: 9
• Category: Article
• ISSN: 0952-3499
• DOI: 10.1002/(sici)1099-1352(199603)9:2<158::aid-jmr257>3.0.co;2-n

✦ Synopsis

We have developed a family of receptors designed to bind flavin derivatives using specific hydrogen bond interactions. These synthetic host molecules provide a model for specific hvoenzyme-cofactor interactions, allowing isolation and observation of the effects of hydrogen bonding on flavin NMR. We describe here the use of one of these receptors to study the effects of hydrogen bonding to 0(2), N(3), and O(4) on flavin 'H and 'jC NMR.