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Model studies on total synthesis of the chartellines, spirocyclic β-lactam alkaloids from a marine bryozoan

✍ Scribed by Xichen Lin; Steven M Weinreb

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
66 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

A chartelline alkaloid model system containing a spirocyclic b-lactam moiety and a,b-unsaturated imine has been constructed from isatin using a Staudinger imine-ketene cycloaddition and an addition to an N-activated g-lactam as key steps.

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