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Model for Alternative Splicing of Insulin Receptor in Myotonic Dystrophy Type 1

✍ Scribed by E. A. Tonevitsky; E. V. Trushkin


Publisher
Springer US
Year
2009
Tongue
English
Weight
261 KB
Volume
147
Category
Article
ISSN
0007-4888

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## Abstract Myotonic dystrophy type1 (DM1) is a multisystemic disorder caused by a CTG repeat expansion in the __DMPK__ gene. Aberrant mRNA splicing of several genes has been reported to contribute to some of the symptoms, including myotonia and insulin resistance, but the cause of muscle wasting i