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Model for a Helical Bundle Channel Based on the High-Resolution Crystal Structure of Trichotoxin_A50E †

✍ Scribed by Chugh, J. K.; Brückner, H.; Wallace, B. A.

Book ID
127084381
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
635 KB
Volume
41
Category
Article
ISSN
0006-2960

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Coumarin antibiotics, such as clorobiocin, novobiocin, and coumermycin A1, inhibit the supercoiling activity of gyrase by binding to the gyrase B (GyrB) subunit. Previous crystallographic studies of a 24-kDa Nterminal domain of GyrB from E. coli complexed with novobiocin and a cyclothialidine analog