✦ LIBER ✦

Model-Based Statistical Procedures for the Analysis of in Vitro Mutagenesis Assays

✍ Scribed by John Kaldor

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 792 KB
Volume: 28
Category: Article
ISSN: 0323-3847
DOI: 10.1002/bimj.4710280417

No coin nor oath required. For personal study only.

✦ Synopsis

A number of short-term screening assays for potential chemical carcinogens and mutagenainvolve the meaeurement of mutation rates in in viffo cell populations. In this paper, statistical procedures are proposed for the analysis of results from these aseays. The procedures, which are based on previously developed stochastic models of cell growth and mutation, include hypothesis tests for the comparison of mutation rates in treated and control cultures. and estimation and hypotheak tests for the parameters of a linear mutagenesis dose-response. Computer eimulation is usedto validate the methods, and they are illustrated by an analysis of data obtained under the mouse lJT!1phOm8 mutagenesis protocol.

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