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Model-based prediction of monoclonal antibody retention in ion-exchange chromatography

✍ Scribed by Guélat, Bertrand; Delegrange, Lydia; Valax, Pascal; Morbidelli, Massimo

Book ID
120443675
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
747 KB
Volume
1298
Category
Article
ISSN
1873-3778

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## Abstract Recent experimental studies have shown a reduction in dynamic‐ binding capacity for both monoclonal antibodies and antigen‐binding fragments at very low conductivity, conditions that should generate the greatest electrostatic attraction. This behavior has been attributed to the steric a