✦ LIBER ✦

Mode of action of glyphosate inCandida maltosa

✍ Scribed by Rüdiger Bode; Christian Melo; Dieter Birnbaum

Publisher: Springer
Year: 1984
Tongue: English
Weight: 297 KB
Volume: 140
Category: Article
ISSN: 0302-8933
DOI: 10.1007/bf00409776

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✦ Synopsis

The broad-spectrum herbicide glyphosate inhibits the growth of Candida maltosa and causes the accumulation of shikimic acid and shikimate-3-phosphate. Glyphosate is a potent inhibitor of three enzymes of aromatic amino acid biosynthesis in this yeast. In relation to tyrosine-sensitive 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase and dehydroquinate synthase, the inhibitory effect appears at concentrations in the mM range, but 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase is inhibited by micromolar concentrations of glyphosate. Inhibition of partially purified EPSP synthase reaction by glyphosate is competitive with respect to phosphoenolpyruvate (PEP) with a Ki-value of 12 microM. The app. Km for PEP is about 5-fold higher and was 62 microM. Furthermore, the presence of glyphosate leads to derepression of many amino acid biosynthetic enzymes.

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