Moclobemide and specific serotonin re-uptake inhibitor combination treatment of resistant anxiety and depressive disorders
✍ Scribed by D. Bakish; C. L. Hooper; D. L. West; C. Miller; A. Blanchard; F. Bashir
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 377 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0885-6222
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✦ Synopsis
This retrospective study was undertaken with the objective of determining how effective and safe moclobemide, a specific and reversible inhibitor of monoamine oxidase-A (RIMA), is when used in combination with specific serotonin re-uptake inhibitors (SSRIs), in a clinical setting. A thorough chart review was done of all patients with affective and anxiety disorders seen at our centre who received combination treatment with moclobemide and an SSRI. Combination moclobemide-SSRI treatment demonstrated good efficacy in treating treatment-resistant patients. The combination treatment was well tolerated with very few drug interactions. Dosages should be started low, titrated slowly and carefully, and patients should be monitored closely.